Delightful High-Protein Spinach & Artichoke Chicken Casserole Recipe

Comfort meets nutrition in this delectable spinach and artichoke chicken casserole that packs a powerful high-protein punch.

Creamy textures and rich flavors dance across your plate, creating an irresistible meal.

Tender chicken blends seamlessly with vibrant spinach and hearty artichokes in this wholesome dish.

Each bite delivers a perfect balance of protein and vegetables, making dinner both satisfying and nourishing.

The casserole transforms simple ingredients into a memorable culinary experience.

Cheese melts into every crevice, adding depth and warmth to this comforting meal.

Prepare to savor a dish that feels like a warm hug from the kitchen.

Quick Recipe Overview

Prep Time: 10 minutes

Cook Time: 25 minutes

Total Time: 35 minutes

Calories: 320 kcal

Servings: 6

Ingredients for High-Protein Spinach and Artichoke Chicken Casserole

• Chicken: Lean protein powerhouse that adds substantial muscle-supporting nutrients and creates a hearty main dish texture.
• Greek Yogurt: Tangy protein booster that ensures creamy consistency and adds subtle nutritional depth.

• Cream Cheese: Silky smooth ingredient that delivers rich, indulgent flavor and helps create luxurious casserole texture.
• Mozzarella: Melty cheese that provides stretchy, gooey goodness and enhances overall cheesy experience.
• Parmesan: Sharp, nutty cheese that contributes intense flavor complexity and delightful savory notes.

• Garlic Powder: Aromatic spice that infuses deep, concentrated garlic essence without raw garlic intensity.
• Onion Powder: Subtle seasoning that adds gentle, rounded onion undertones and balanced background flavor.
• Salt: Essential mineral that amplifies and harmonizes all other taste elements in the dish.
• Black Pepper: Warm, slightly spicy seasoning that introduces gentle heat and aromatic complexity.
• Red Pepper Flakes: Zesty spice that delivers subtle, vibrant heat and exciting flavor dimension.

• Spinach: Nutrient-dense green that introduces earthy freshness and vibrant color to the casserole.
• Artichokes: Tender, slightly tangy vegetable that provides unique texture and sophisticated flavor profile.

• Almond Flour: Low-carb, crunchy ingredient that creates golden, crisp exterior with nutty undertones.
• Pork Rinds: Protein-rich alternative.

Tools That Help Bake This Protein-Packed Casserole

• Large mixing bowl: Perfect for combining creamy ingredients and mixing chicken mixture.
• 9×13-inch baking dish: Essential for assembling and baking the casserole evenly.
• Measuring cups and spoons: Crucial for accurate ingredient proportions.
• Cheese grater: Helpful for grating fresh mozzarella and Parmesan.
• Wooden spoon or spatula: Great for stirring and mixing ingredients smoothly.
• Cutting board: Needed for chopping spinach and preparing ingredients.
• Sharp knife: Used for chopping vegetables and preparing ingredients.

How to Cook a Spinach and Artichoke Chicken Dish

• Fire Up the Oven

Crank the oven to a toasty 375F and give a quick spray of cooking oil to a 9×13 baking dish. Get ready for some serious flavor magic!

• Whip Together the Creamy Goodness

Grab a big mixing bowl and blend Greek yogurt, cream cheese, and cheesy friends until silky smooth. Sprinkle in garlic powder, onion powder, salt, pepper, and a dash of red pepper flakes for that extra kick.

• Mix and Mingle the Ingredients

Toss in shredded chicken, chopped spinach, and artichoke pieces. Stir everything until each morsel is dressed in that luxurious cream sauce.

• Create Your Flavor Masterpiece

Pour the mixture into the baking dish, spreading it out evenly. Crown your creation with a sprinkle of extra cheese and a crunchy almond flour or pork rind topping.

• Bake to Perfection

Slide the dish into the hot oven and let it sizzle for 20-25 minutes. You’ll know it’s ready when it’s bubbling and looking irresistibly golden.

• Serve and Savor

Let the casserole cool for a quick 5 minutes, then dive in while it’s warm and wonderful. Enjoy your protein-packed feast!

Options to Boost Protein or Veggie Content

• Prepare the casserole ahead of time and refrigerate until ready to bake, perfect for busy weeknights or make-ahead meal planning.
• Swap chicken for Greek yogurt-marinated turkey, lean ground beef, or tofu to create different protein variations that suit your dietary needs.
• Replace almond flour/pork rinds topping with crushed pork rinds or cheese crisps for an extra crunchy, zero-carb alternative that keeps the dish keto-friendly.
• Use cashew cream cheese, nutritional yeast, and dairy-free mozzarella to create a plant-based version that maintains the creamy, rich texture of the original recipe.
• Add roasted bell peppers, diced zucchini, or mushrooms to increase vegetable content and create more nutritional depth without compromising the casserole's delicious flavor profile.

Serve This High-Protein Casserole Hot and Bubbly

• Comfort Food Companion: Pair this creamy casserole with a light, crisp green salad to balance the rich flavors and add freshness.
• Protein Power Plate: Serve alongside quinoa or cauliflower rice to boost protein content and create a complete, satisfying meal.
• Mediterranean Magic: Garnish with fresh chopped herbs like basil or parsley, and add a dollop of Greek yogurt for extra tang and creaminess.
• Low-Carb Love: Skip traditional sides and enjoy the casserole as a standalone dish for a hearty, filling keto-friendly meal that's packed with nutrition.

Casserole Storage Tips for Busy Weeknights

• Dice and cook chicken in advance during weekly batch cooking to save 20-30 minutes when assembling this casserole.
• Store leftovers in airtight containers for up to 4 days, ensuring maximum flavor and texture when reheating at 350F for 10-15 minutes.
• Wrap individual portions in freezer-safe containers or wrap tightly with plastic and aluminum foil, lasting up to 3 months for quick future meals.
• Divide casserole into single-serving ramekins before baking, creating easy grab-and-go meals for busy weekdays or meal prepping lunch options.

Hearty High-Protein Spinach and Artichoke Chicken Casserole

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4.8 from 39 reviews

• Total Time: 35 minutes
• Yield: 7 1x

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Description

Comfort meets nutrition in this high-protein spinach and artichoke chicken casserole, blending creamy textures with wholesome ingredients. Hearty layers of tender chicken, leafy spinach, and tangy artichokes promise a satisfying meal that nourishes and delights.

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Ingredients

Scale 1x2x3x

• 3 cups (720 ml) shredded chicken, cooked (rotisserie works great!)
• 4 oz (113 g) cream cheese, softened
• ½ cup (120 ml) Greek yogurt (or sour cream)
• 1 (14 oz/400 g) can artichoke hearts, drained and chopped
• 3 cups (720 ml) fresh spinach, chopped
• 1 cup (240 ml) mozzarella cheese, shredded (divided)
• ¾ cup (180 ml) Parmesan cheese, grated (divided)
• 1 tsp garlic powder
• ½ tsp onion powder
• ½ tsp salt
• ¼ tsp black pepper
• ¼ tsp red pepper flakes (optional, for spice)
• 2 tbsps almond flour or crushed pork rinds (for a crunchy topping)

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Instructions

1. Oven Preparation: Heat the oven to 375°F (190°C) and lightly coat a 9×13-inch baking dish with cooking spray or butter.
2. Creamy Fusion: Whisk together Greek yogurt, cream cheese, mozzarella, Parmesan, garlic powder, onion powder, salt, black pepper, and red pepper flakes in a spacious mixing bowl until the mixture becomes uniformly smooth and well-integrated.
3. Protein and Vegetable Incorporation: Gently fold shredded chicken, finely chopped spinach, and diced artichokes into the creamy blend, ensuring every ingredient is thoroughly coated and distributed evenly.
4. Baking and Topping: Transfer the mixed contents to the prepared baking dish, spreading it into a uniform layer. Generously sprinkle additional mozzarella, Parmesan, almond flour, and crushed pork rinds across the surface to create a crisp, golden topping.
5. Culinary Transformation: Place the casserole in the preheated oven and bake for 20-25 minutes, watching for a bubbling texture and beautifully bronzed top that signals perfect doneness.
6. Serving Presentation: Remove from oven and allow the casserole to rest for 5 minutes, which helps set the creamy consistency, then serve warm for maximum flavor and enjoyment.

Notes

• Use rotisserie chicken or freshly grilled chicken breast for maximum flavor and protein content, ensuring consistent texture throughout the casserole.
• Drain spinach and artichokes thoroughly to prevent excess liquid, which could make the casserole watery and compromise the creamy consistency.
• Swap Greek yogurt with dairy-free alternatives like coconut yogurt for lactose-intolerant individuals, maintaining the recipe’s creamy texture and nutritional profile.
• Toast almond flour or crushed pork rinds before sprinkling to intensify the crunch and develop a deeper, nuttier flavor profile for the casserole’s top layer.

• Prep Time: 10 minutes
• Cook Time: 25 minutes
• Category: Dinner, Lunch
• Method: Baking
• Cuisine: American

Nutrition

• Serving Size: 7
• Calories: 300
• Sugar: 2 g
• Sodium: 600 mg
• Fat: 18 g
• Saturated Fat: 8 g
• Unsaturated Fat: 10 g
• Trans Fat: 0 g
• Carbohydrates: 10 g
• Fiber: 3 g
• Protein: 30 g
• Cholesterol: 90 mg